Drug Delivery
"The right drug in the right dose to the right patient at the right time."
— The 5 R's of Medication Administration
Drug delivery deals with the controlled and targeted release of therapeutic agents, which is vital for precision medicine, as it allows for the localized treatment of specific diseases or tissues, reducing the exposure of healthy tissues to the medication. My research involves designing drug carriers, such as nanoparticles, nanofibers, and metal-organic frameworks, that can respond to various stimuli, including pH, temperature, and enzymes, and release their therapeutic cargo at the precise site of action. I study the underlying mechanisms governing controlled and sustained drug release, enabling the design of therapeutics that maintain optimal drug concentrations over extended periods, reducing the frequency of administration, and enhancing patient convenience, compliance, and therapeutic success. Currently, I am working on reviews and original research utilizing various nanostructures and 3D printing.
Publications
1. A review on allopathic and herbal nanofibrous drug delivery vehicles for cancer treatments
Biotechnology Reports
DOI: 10.1016/J.BTRE.2021.E00663
2. A critical analysis of the recent developments in multi-stimuli responsive smart hydrogels for cancer treatment
Current Opinion in Biomedical Engineering
DOI: 10.1016/J.COBME.2022.100424
3. A Review on Curcumin-Loaded Electrospun Nanofibers and their Application in Modern Medicine
JOM
DOI: 10.1007/S11837-022-05180-9
4. Recent advances in electrospun allopathic anti-cancerous drug delivery systems
Materials Today: Proceedings
DOI: 10.1016/J.MATPR.2021.01.077
Book Chapters
1. Nanotechnology for diagnosis and treatment of dental and orthopedic diseases
Emerging Nanotechnologies for Medical Applications, Elsevier
DOI: 10.1016/B978-0-323-91182-5.00003-6
2. Quantum Dots: The Next Generation Candidate for Biomedical Imaging
Applications of Nanotechnology in Biomedical Engineering, Taylor & Francis (Accepted)
Correspondence: Goutam Thakur
Preprints
1. Physicochemical investigations of nanoemulsified, curcumin-loaded, crosslinked k-carrageenan hydrogels
2. Fostering K-carrageenan Hydrogels with the Power of Natural Crosslinkers: A Comparison between Tender Coconut Water and Potassium Chloride for Antibacterial Therapy
3. Evaluation of the antibacterial activity of silver-doped curcumin-loaded zeolitic imidazolate framework-8 against methicillin-sensitive and -resistant Staphylococcus aureus
4. Fabrication and Characterization of Tamarind gum–Hydroxypropyl-beta-cyclodextrin-based semi-interpenetrating hydrogel network and In-vitro release of Moxifloxacin
5. Ultrasound-guided Drug Delivery and Tissue Engineering
6. Effect of Curcumin-adsorbed ZnO Nanoparticles on the Physical, Mechanical, and Antibacterial Properties of Κ-carrageenan Hydrogels
Projects in Progress
1. Review of applications of herbal extracts in electrospun nanofibers
Correspondence: Anindita Laha, Seeram Ramakrishna
2. A systematic review of peptide nanofibers versus polymer nanofibers for chemotherapy—A Major Test of Strength
Correspondence: Anindita Laha, Seeram Ramakrishna
3. Curcumin-adsorbed zeolitic imidazolate framework-8 in gelatin–carrageenan cryogels for biomedical applications
To be on ChemRxiv
Correspondence: Goutam Thakur
4. Recent Studies on the efficiency of electrospun nanofibers for Ocular Drug Delivery
Correspondence: Anindita Laha, Seeram Ramakrishna
5. Development of curcumin adsorbed copper oxide nanoparticles impregnated in gelatin–chitosan cryogels for biomedical applications
To be on ChemRxiv
Correspondence: Goutam Thakur
6. Fabrication of 3D Printed Polymer Based Microneedles: Optimization and Characterization
Manuscript submitted to 'Chemical Papers' journal
Correspondence: Goutam Thakur, Shounak De
7. Curcumin-adsorbed Zeolitic Imidazolate Frameworks in Electrospun Bioresorbable Nanofibers as a Drug Delivery System for Biomedical Applications: Synthesis and Antibacterial Potency against Staphylococcus aureus
Correspondence: Goutam Thakur